Our study found increased expression of anti-apoptotic genes (Bcl-2 and Bcl-xL) and upstream apoptosis regulators (cIAP2 and FLIP), along with decreased expression of pro-apoptotic genes (Bad, Bax, and Bak), in both Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) tissues compared to normal esophageal tissues from obese patients. This evidence concerns the gene CFLAR and Barrett esophagus.