AKT1 and obesity due to melanocortin 4 receptor deficiency: The correlation analysis revealed a positive correlation of apoptotic factors Bad, Bak, and Bax (Fig. 6 panels A, B, and C), anti-apoptotic factors Bcl-2 and Bcl-XL (Fig. 6 panels D and E), PKC-δ (Fig. 6 panel F), inflammatory mediators AKT and NF-κB (Fig. 6 panels I and J), IGF-1 (Fig. 6 panel L), proliferation marker Ki-67 ( Fig. 6 panel K), and regulators of apoptosis cIAP2 and FLIP (Fig. 6 panels G and H) with obesity.