The qRT-PCR analysis revealed significantly increased folds change in mRNA expression of PKC-δ, IGF-1 (p = 0.009 and p = 0.001), Akt (p = 0.03 and p = 0.03), NF-κB (p = 0.02 and p = 0.007), and proliferation marker Ki67 (p = 0.01 and p = 0.0004) in BE and EAC compared to normal esophageal tissue (Fig. 2 panel B). The gene discussed is IGF1; the disease is Barrett esophagus.