CDH1 and colorectal carcinoma: A 2013 study reported that FadA facilitates CRC progression by modulating E-cadherin/β-catenin signaling.158 Later in 2019, FadA was shown to work in concert with Annexin A1 to activate β‐catenin in CRC cells, thus accelerating cancer growth.110 An excreted amyloid-like form of FadA was also shown to promote CRC progression by serving as a scaffold for biofilm formation and host cell adherence.159 Additionally, this study found that production of FadA increases acid tolerance, which may be an important mechanism to facilitate GI translocation.