In addition to CRC, Fn appears to have similar associations with various other tumor types throughout the body.160 Recent studies have identified an enrichment of Fn in oral cancer, but there is still an overall dearth of evidence describing Fn subspecies associations among head and neck cancers (HNCs).5 A recent meta-analysis of 17 publications reported Fnn as the most prevalent subspecies within HNC,161 but given the limited amount of supporting evidence, it will be interesting to observe whether this trend holds as additional studies are performed in the future. This evidence concerns the gene FN1 and head and neck cancer.