Liver fibrosis is marked by increased oxidative stress [43] and patients carrying the PNPLA3 I148M variant demonstrated an increase in systemic oxidative stress as quantified in serum levels of soluble NOX2‐derived peptide (sNOX2‐dp) and 8‐isoprostaglandin F2α (8‐iso‐PGF2α) [66]. Here, PNPLA3 is linked to Hepatic fibrosis.