PNPLA3 and metabolic dysfunction-associated steatotic liver disease: A human pluripotent stem cell (hPSC)‐derived multicellular liver culture system containing hPSC‐derived hepatocytes, HSCs and macrophages and exposed to a lipotoxic milieu containing glucose, insulin, palmitic acid and oleic acid, that is, mimicking risk factors in NAFLD patients showed an increased expression in HSCs activation markers in those HSCs carrying PNPLA3 I148M with elevated levels of IL6/STAT3, which coincided with a reduction in retinol content and quiescence marker PPARγ [91], as shown before [30].