Interestingly, previous studies further indicated that USP11 inhibition may protect amyloid aggregation-induced paralysis in C elegans and increase BACE1 degradation in AD model mice (Basic et al, 2021; Wu et al, 2022), which may also contribute to the ameliorated amyloid deposition induced by IsoLiPro. This evidence concerns the gene USP11 and Alzheimer disease.