MAPT and Alzheimer disease: AD is pathologically characterized by senile plaques and neurofibrillary tangles, formed by β-amyloid (Aβ) and hyperphosphorylated tau protein in the brain, respectively, which lead to progressive synaptic and neuronal loss and culminating in cognitive deterioration and dementia (Freitag et al, 2022; Pritam et al, 2022).