Currently, several USPs members, such as USP9 (Köglsberger et al, 2017), USP10 (Wei et al, 2022), USP11 (Yan et al, 2022), and USP25 (Zheng et al, 2022), have been identified to accelerate the progression of AD by targeting tau or Aβ precursor protein (APP). Here, MAPT is linked to Alzheimer disease.