IHC staining and Western blotting on brain tissues of transgenic AD mice (both 3xTg and 5xFAD) showed that, after treatment with IsoLiPro, the protein levels of USP11 were significantly reduced in the cortex and hippocampus, compared with double-distilled water-treated (ddH2O) control mice (Figs. 2F–H and EV3I,J). Here, USP11 is linked to Alzheimer disease.