A broad distribution of m6A modifications across the CDS and 3’UTR has been demonstrated to regulate the expression of several targets of TDP43 (McMillan et al, 2023), a nuclear RNA-binding protein integrally involved in RNA processing and previously associated with HD pathology (Sanchez et al, 2021; Tada et al, 2012). The gene discussed is TARDBP; the disease is Huntington disease.