PTEN and Familial prostate cancer: For example, in phosphatase and tensin homolog (PTEN)-null prostate cancer cells, Akt serine/threonine kinase (AKT) interacts with and directly phosphorylates NSD2 at S172, preventing NSD2 degradation by the CRL4–chromatin licensing and DNA replication factor 1 (CRL4Cdt1) complex95.