In this study, we examined the effect of a single injection of synthetic psilocybin (PSIL) or psilocybin-containing psychedelic mushroom extract (PME) on excessive self-grooming, head-body twitches, anxiety and other behavioral phenotypes in SAPAP3 KO mice, employing a randomized, controlled design with extended follow-up. Here, DLGAP3 is linked to Anxiety.