While some regions reacquired PRAD histological features (moderate-to-well-differentiated adenocarcinoma harboring KRT8 and AR expression), the predominant histology was high-grade ASCL1− NEPC with sarcomatoid-like features (Fig. 8e–g, Extended Data Fig. 10h and Supplementary Fig. 7b–d). The gene discussed is KRT8; the disease is adenocarcinoma.