Recent research has suggested that casitas B lymphoma-b (Cbl-b), an E3 ubiquitin ligase, may serve as a potential biomarker for myocardial infarction, providing evidence that Cbl-b expression is significantly lower in MI patients than in control individuals, as demonstrated by analyses of both a public database and 20 peripheral blood samples3. The gene discussed is CBLB; the disease is myocardial infarction.