BAG3 and Alzheimer disease: Although we have not validated if the overexpression of BAG3 specifically in astrocytes can prevent AD-like pathology and cognitive deficits induced by TBI in this study, increased BAG3 in astrocytes is probably a protective and compensatory response of astrocytes to degrade tau in pathological conditions because there is no ptau found in astrocytes (Supplementary Fig. 2g) in animal models with TBI.