Fourth, although we have identified BAG3 as a downstream mediator of TBI-induced ALP dysfunction, tau accumulation, gliosis, and cognitive deficits, TBI may alter the expression of many other genes associated with tau protein homeostasis [22] that may contribute to this detrimental phenotype, and the function of these genes in the context of TBI and AD warrants future study. Here, MAPT is linked to Cognitive impairment.