HTR1A and Cognitive impairment: Although the efficacy of opto-genetic stimulation of the 5-HT neuron terminals and 5-HT receptor subtype-positive neurons in the PFC are needed as future experiments, these data suggest that pharmacological and opto-genetic activation of serotonergic neurons attenuates social and cognitive deficits and hyper-glutamatergic signaling in the PFC of prenatal VPA mice via 5-HT1A receptors but fails to attenuate repetitive behavior by simultaneous activation of 5-HT1A receptors.