Multiple glucose transporters including GLUT1 and GLUT3 are expressed in articular chondrocytes and regulated by both cartilage anabolic and catabolic signals.65–67 Genetic studies have demonstrated that GLUT1 is required for articular chondrocyte survival and joint cartilage maintenance in adult mice particularly in the context of surgery-induced osteoarthritis.68,69 Furthermore, forced expression of GLUT1 was sufficient to ameliorate joint cartilage loss in the surgery-induced osteoarthritis mouse model, supporting impaired glucose metabolism as a driver in osteoarthritis progression.68 The gene discussed is SLC2A1; the disease is osteoarthritis.