NR4A2 and early-onset autosomal dominant Alzheimer disease: Notably, AQ has been reported to stimulate the transcriptional function of nuclear receptor-related 1 protein (Nurr1) through physical interaction with its ligand binding domain, which could further improve behavioral deficits and cognitive function of Parkinson’s disease and Alzheimer’s disease in the animal model, both of which are associated with aging [46, 47].