PRKN and Alzheimer disease: Similarly, in terms of MSR-mitophagy markers, ROC tests compared AD patients against the HC group (Fig. 1d), and the AUC for PINK1 was 0.952 (95% CI: 0.861–0.982) and 0.921 (95% CI: 0.857–0.977) for Parkin, indicating MSR is a suitable diagnosis marker panel.