Assessing the utility of MSR-UPRmt levels to discriminate between clinically defined AD and HC, we found an area under the ROC curve (AUC) of 0.956 (95% CI: 0.920–0.991) for ATF4, 0.926 (95% CI: 0.875–0.976) for ATF5, and 0.936 for CHOP (95% CI: 0.891–0.982; Fig. 1c). Here, ATF4 is linked to Alzheimer disease.