Moreover, NMN lowered the protein levels of 6E10 (full-length APP, C99), BACE-1, and CTFs in mouse neuroblastoma N2s cells (Fig. 2c, e–i), suggesting a possibility of amelioration in Aβ pathology of NMN by inhibition of BACE-1 activity. Here, BACE1 is linked to neuroblastoma.