The important role of MIC26 in channelling nutrient excess from glucose into lipids underscores its reported links to obesity (Tian et al, 2017) and diabetes (Lamant et al, 2006) as it known that ectopic lipid accumulation is a common feature of the development of metabolic diseases including NAFLD and insulin resistance. This evidence concerns the gene APOO and obesity due to melanocortin 4 receptor deficiency.