APOO and Hyperglycemia: However, the observed increased glucose uptake in MIC26 KO-N (compared with WT-N) was abolished in MIC26 KO-H (compared with WT-H) and accordingly accompanied by no increase in GLUT3 levels showing that the high amounts of glucose in MIC26 KO cells grown in hyperglycemia cannot be explained by an increased glucose uptake under these conditions (Fig 3I).