APOO and Hyperglycemia: A total of 21,490 genes were obtained after the initial mapping of the RNA-Seq data, of which 2,933 were significantly altered in normoglycemic MIC26 KO compared with WT cells (fold change of ±1.5 and Bonferroni correction P ≤ 0.05), whereas in hyperglycemia, MIC26 KO had 3,089 significantly differentially expressed genes as compared with WT-N cells.