APOO and Hyperglycemia: We found that ATP citrate lyase (ACLY, Fig S8G), acetyl-Co-A carboxylase (ACACA, Fig S8H and I) which converts acetyl-CoA into malonyl-CoA, fatty acid synthase (FASN, Fig S8J and K) and acetyl-CoA desaturase (SCD, Fig S8L and M) were increased in normoglycemia in MIC26 KOs but mostly unchanged in hyperglycemia.