CALR and acute myeloid leukemia: From the adult patients with AML, one developed secondary AML from myelodysplastic syndrome with a CALR mutation2 while the other had de novo disease with a t(8;21) translocation.9 Of all the reported patients, only Beauvais et al7 confirmed both micro-deletion 1q21.1 and germline mutation of RBM8A in a patient with T-cell acute lymphoblastic leukemia.