CREBBP and acute myeloid leukemia: Somatic NGS from the bone marrow identified four incidental point mutations of unknown significance in STAT5B, PPMD1, IKZF2, and CREBBP, at a 50% variant allelic frequency (VAF) which have not been reported previously in TAR or Ph+AML.4,18 To further investigate these mutations, we queried the NCBI ClinVar database.19PPMD1 (p.Ile496Val) and CREBBP (p.Val238Leu) were cataloged in ClinVar and predicted to be likely benign.