BMP2 and cancer: However, a methodological issue in their analysis was the authors' inclusion of multiple episodes of localized basal and squamous cell carcinomas of the skin from the same patients in their study, which is not consistent with the reportable malignancy criteria set forth by the Commission on Cancer.31 Kelly et al32 in their analysis of 467,916 Medicare patients found that not only BMP-2 was not associated with an increased risk of cancer but also a mild protective effect was identified in women (OR 0.93, 95% CI 0.9-0.97).