Recently, 15 human proteins,besides angiotensin-converting enzyme 2 (ACE2), have been identifiedas critical host factors for SARS-CoV-2 replication and infection,including COG3.39 This protein interactswith SARS-CoV-2 proteins ORF3B, ORF6, ORF7A, and ORF7B, which havealso been related to inflammation and fibrotic processes,40 both hallmarks of patients admitted to the ICU. The gene discussed is ACE2; the disease is infection.