EPHA2 and infection: Indeed, it has been proposedthat this receptor is related to the entry of a plethora of viruses,including SARS-CoV-2, and its expression has been correlated withsevere symptoms of the disease.63 SARS-CoV-2spike S1 protein induces epithelial injury through the activationof the Rock2/Rho pathway, among others.64 Interestingly, Rho-associated coiled-coil containing protein kinase2 (ROCK2) is a target of ephrin receptors, as EPHA2, but is also associatedwith the infection.