Rho proteins regulateactin polymerization to form structures related to cell morphology,cell movement, attachment, and endocytosis, being this latter processdirectly connected to COVID-19 infection in the virus pre-entry andendocytosis.62 The ephrin type-A membranereceptor 2 (EPHA2), upregulated in the mild/severe COVID-19 samplesanalyzed, is upstream of Rho signaling. This evidence concerns the gene EPHA2 and COVID-19.