LSM2 and viral infectious disease: The SF3b complex is an intrinsic componentof the functional U2 small nuclear ribonucleoprotein (snRNP), facilitatingspliceosome assembly and activation.49 Thenonstructural protein NSP16 from SARS-CoV-2 binds mRNA recognitiondomains of U1/U2 snRNAs and disrupts mRNA splicing.47 Interestingly, this study also identifies 40S ribosomalprotein as a key point to disrupt protein translation, a protein thatwas also found to increase upon viral infection.