Heterozygous missense variants have been identified in the sodium-gated potassium channel gene KCNT1 in more than 200 individuals exhibiting a wide spectrum of developmental and epileptic encephalopathies (DEEs), with the majority being classified as either epilepsy of infancy with migrating focal seizures or autosomal dominant or sporadic sleep-related hypermotor epilepsy (Barcia et al., 2012; Bonardi et al., 2021; Heron et al., 2012). The gene discussed is KCNT1; the disease is epilepsy.