For example, the expressionof all of the top 2–4 E2-upregulated or E2-downregulated proteins(Table 1) has beenshown to be associated with breast cancer,38,39 except for endosome/lysosome-associated apoptosis and autophagyregulator 1 (ELAPOR1), protein FAM83H (FAM83H), and pyridoxal-dependentdecarboxylase domain containing 1 (PDXDC1), whose roles in breastcancer remain unreported. The gene discussed is SACK1H; the disease is breast cancer.