While this could indicate that morphologically high-grade KAT6B/A::KANSL1 uterine sarcomas originate from different progenitor cells in the uterus, in the light of the divergent immunohistochemical profiles, it is perhaps more likely that high-grade histologic transformation in KAT6B/A::KANSL1 uterine sarcomas represents a shift in cellular context to either a more primitive cellular state or a transdifferentiated cellular state. The gene discussed is KANSL1; the disease is uterine corpus sarcoma.