MAPT and Alzheimer disease: Another characteristic feature of AD is the abnormalaccumulationof tau protein in the form of neurofibrillary tangles within neurons.25−27 Tau protein plays a crucial role in stabilizing microtubules, whichare essential for maintaining the structure and function of neurons.In AD, tau protein becomes hyperphosphorylated, leading to its misfoldingand aggregation into neurofibrillary tangles (Figure 1B).