Furthermore, previous studies suggested that the Jab1/CSN5 signaling pathway has a close association with the 5-HT6 receptor (5-HT6R) (Chaumont-Dubel et al. 2020) that may play a crucial role in epileptogenesis and cognitive impairment (Liu et al. 2019, Chaumont-Dubel et al. 2020), which partly support the top 6, 9, and 10 prediction results (Supplementary Table S12). The gene discussed is HTR6; the disease is Cognitive impairment.