With the advent of anti-DLL3 therapies, studies of interrelationships between different molecules still need to be included, such as thyroid transcription factor-1 (TTF-1), which is involved in the differentiation of lung epithelial cells and is commonly expressed in high-grade lung and neuroendocrine adenocarcinomas, or Ki-67 protein (MKI67) which is a cellular marker for proliferation, found in the nucleus of cancer cells that are actively growing and dividing [14, 15]. This evidence concerns the gene TTF1 and cancer.