Ferroptosis has been reported to inhibit tumorigenesis in different models, for example, lung cancer,[35] colorectal cancer,[36] and hepatocellular carcinoma,[37] which has potential as an innovative strategy for therapeutic targeting.[38] In the context of BLCA, few studies have elucidated the specific role of ferroptosis, particularly focusing on the xCT protein and the underlying mechanisms by which it affects disease progression. This evidence concerns the gene SLC7A11 and hepatocellular carcinoma.