GPX4 and cancer: Glutathione peroxidase 4 (GPX4) uses GSH to enzymatically reduce lipid hydroperoxides to lipid alcohols to protect cells against membrane lipid peroxidation and thereby exert a suppressive effect on ferroptosis.[6] A furry amount of evidence demonstrates that the induction of ferroptosis may play a significant role, either alone or in combination, in tumor suppression.[7] Despite the dysregulation of ferroptosis in cancer cells is emerging as a promising target in cancer therapy,[7, 8] the role and internal mechanism of ferroptosis in BLCA is still limited.