Other targets included components of TGFβ, NOTCH, PI3K, WNT/FZD/GSK3, and SEMA6A signaling, several of which have been implicated in modulating NF-κB activity in HNSCC or other contexts (Supplementary Tables S1A and S1B; Fig. 1A–C; refs. 23–27). Here, TGFB1 is linked to head and neck squamous cell carcinoma.