TNF and head and neck squamous cell carcinoma: Recently, we demonstrated that one of the targets identified in our RNAi screening, the G2/M checkpoint kinase WEE1, promotes TNFα-induced co-activation of canonical IKKα/β, nuclear translocation of RELA, and NF-κB transactivation, as well as TNFα-induced phosphorylation of known WEE1 target CDC2, identifying a novel role of TNFα in co-activation of these kinases mediating G2/M cell-cycle arrest and of NF-κB prosurvival signaling in HNSCC (5).