Mutations in TNFRSF14 may lead to a tumor-supportive microenvironment through an increase in the production of cytokines recruiting T follicular helper cells (19), and mutations in B2M may lead to loss of expression of human leukocyte antigen class 1, which impairs CD8+ cytotoxic T-cell binding (20). Here, TNFRSF14 is linked to neoplasm.