PPIB and Alzheimer disease: A total of 36 blood lipids and lipoproteins items as exposure traits had effects on the main outcome traits of AD: (1) 32 of which were positively associated with the main outcome traits, seven of which, e.g., apolipoprotein B (ieu-b-108), were positively associated with EOAD (finn-b-AD_EO) and LOAD (finn-b-AD_LO); free cholesterol in IDL (met-c-868) was positively associated with EOAD (finn-b-AD_EO); four of which, e.g., phospholipids in small LDL (met-d-S_LDL_PL), were positively associated with LOAD (finn-b-AD_LO), as shown in Figure 3A.