CX3CL1 and ischemic disease: A positive association among endothelial progenitor cell (EPC) mobilization and levels of circulating FKN in a setting of endothelial activation in patients with SSc recommended that FKN, as an angiogenic chemokine, activates the proliferation and migration of endothelial cells, migration of EPCs, and in vitro formation of a tube‐like structure and stimulates the in vivo formation of new blood vessels even in ischemic disease.13, 82, 83, 84