Several of the substrates that we identified in our screen also exhibited altered cleavage in mucosal biopsies from patients with colitis compared to healthy volunteers, although not necessarily at the same cleavage sites (C3, Hp, Rpl30, Epx, Apoa1, Coro1a, Fga, and Fgb–colitis; Clca1, Myh11–healthy) (Gordon et al., 2019). Here, MYH11 is linked to colitis.