Several of the substrates that we identified in our screen also exhibited altered cleavage in mucosal biopsies from patients with colitis compared to healthy volunteers, although not necessarily at the same cleavage sites (C3, Hp, Rpl30, Epx, Apoa1, Coro1a, Fga, and Fgb–colitis; Clca1, Myh11–healthy) (Gordon et al., 2019). This evidence concerns the gene CLCA1 and colitis.