Dementia and motor‐neuron diseases are associated with accumulation of disordered RBPs, such as TDP‐43 in amyotrophic lateral sclerosis (ALS) and ataxin‐1(ATXN1) in Ataxia (Bossy‐Wetzel et al., 2004). Here, ATXN1 is linked to amyotrophic lateral sclerosis.