In total, there were eighteen L‐R pairs decreased in NPC patients with lymph node metastasis, and the communication probability of five pairs including MIF‐(CD74 + CXCR4), MIF‐(CD74 + CD44), LGALS9‐CD45, IL16‐CD4 and CCL19‐CCR7 were increased in NPC_LNM (Figure S10B,C). Here, IL16 is linked to metastatic malignant neoplasm in the lymph nodes.