To reveal the potential roles of myeloid cells in NPC lymph node metastasis, we identified 12 clusters (4199 cells) including six dendritic cells (DC) subsets (DC1‐CLEC9A, DC2‐C1‐CD1A, DC2‐C2‐CLEC10A, DC3‐C1‐BIRC3, DC3‐C2‐FSCN1 and pDC‐LILRA4), 1 monocyte cluster (Monocyte‐FCN1), 1 neutrophils cluster (Neutrophils‐S100A8), and 4 macrophage clusters (Macrophage‐C1‐CD163, Macrophage‐C2‐APOE, Macrophage‐C3‐C1QA and Macrophage‐C4‐CD14) (Figure 3A and Figure S4A). Here, APOE is linked to nasopharyngeal carcinoma.