NOS3 and Thromboembolism: Endothelial effects of SDMA could also contribute to the risk of thromboembolism by attenuating the normal inhibitory effects of eNOS-derived NO on platelet activation, aggregation and adhesion to the endothelium [126], potentially explaining data associating L-hArg/SDMA ratio with large vessel and cardioembolic stroke subtypes [88,93].