In a population of non-diabetic subjects, SDMA was negatively correlated with insulin resistance in Caucasian, but not African, subjects adjusted for cofounders such as renal function, age, and BMI [71]; and in a cohort of atherosclerotic patients and age-matched controls, circulating SDMA levels were lower in insulin resistant than insulin sensitive individuals [72]. The gene discussed is INS; the disease is Insulin resistance.