Resistance to parathyroid hormone, to thyroid-stimulating hormone, gonadotropins and growth-hormone-releasing hormone. Sometimes associated with short stature, skeletal anomalies, ectopic ossifications, obesity, mental retardation and hypogonadism with incomplete sexual maturation, delayed puberty, oligomenorrhea or SA. This evidence concerns the gene GHRH and obesity due to melanocortin 4 receptor deficiency.