Interestingly, infertile women carrying mutated LHCGR variants, coding for proteins with absent cell surface localization and signal transduction abilities, achieved successful oocyte retrieval and high-quality embryos leading to live births, indicating that LHCGR defects disrupt late folliculogenesis events and ovulation but have no effect on fertilization or embryo development (107). This evidence concerns the gene LHCGR and Infertility.