oCGI Chr11:728884-729383 knockout in LN229 and U251 cell lines markedly decreased the expression of POLR2L gene and glioma stem cell-related genes, CD133 and SOX2. However, such a regulatory relationship was not observed in A172 and SF126 cell lines (Figures 6C and 6D). Here, SOX2 is linked to central nervous system cancer.