After i.c.v. injection of 10 μL of AD1 that had been immunodepleted of Aβ, baseline synaptic transmission remained stable for 2.5 h, and the application of LFS-300 induced significant LTD (Fig. 2A and B), consistent with the proposal that tau in certain Alzheimer’s disease brain extracts can facilitate LTD. This evidence concerns the gene MAPT and Alzheimer disease.