After i.c.v. injection of 10 μL of AD1 that had been immunodepleted of Aβ, baseline synaptic transmission remained stable for 2.5 h, and the application of LFS-300 induced significant LTD (Fig. 2A and B), consistent with the proposal that tau in certain Alzheimer’s disease brain extracts can facilitate LTD. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.