In addition, lipopolysaccharide binding protein (LBP) levels correlated with white-matter changes in the frontal lobe and Clinical Dementia Rating (CDR)-FTLD sum of boxes (SB) scores of clinically symptomatic GRN-FTD patients, indicating that peripheral immune activity correlates with region-specific brain changes and clinically relevant behavior. The gene discussed is LBP; the disease is frontotemporal dementia.