When MF patients were dicothomized according to DAMP levels, those with higher (upper two quartiles of the MF patient population) HMGB1 values had higher frequency of anemia (hemoglobin <10 g/dL), constitutional symptoms, a trend towards higher frequency of leukemic transformation (Table 2) and shorter overall survival, HR 6.7 (95%CI 1.9-23.2), P<0.01 (Figure 3A). The gene discussed is HMGB1; the disease is anemia.