This study aims to investigate the role of S1PR2 in psoriasis, that has not been investigated before.<h4>Methods</h4>Spatial transcriptomics, RT-qPCR, and flow cytometry were used to map the immune cell landscape and its association with metabolic pathways in an imiquimod (IMQ)-induced psoriasis-like inflammation in <i>S1pr2<sup>fl/fl</sup> K14-Cre</i> mice that could not sense sphingosine-1-phosphate (S1P) in the epidermis through the S1PR2 receptor.<h4>Results</h4>Our analysis suggests that S1PR2 in keratinocytes plays a major role in psoriasis-like inflammation compared to other S1PRs. The gene discussed is S1PR2; the disease is psoriasis.