GPT and Hepatic fibrosis: Therefore, we speculate that this discordancecould be owing to overexpression of AST from non-hepatic sources and also delayed clearanceof AST relative to ALT.35,36 Thus, making AST-based algorithmsproblematic in assessing liver fibrosis by overestimating the degree of liver fibrosis.AST:ALT ratio consequently becomes a very unreliable test for estimating significantfibrosis in ART-experienced individuals.