Although serine proteases play a role in normal cellular function, they have been attributed to cell death and apoptosis in the CNS and by inhibiting lead to protective properties.62,63 Serine protease and its inhibition have been targeted with virus-derived immune modulators in rats in response to CNS injury, but more research is needed.64 Another study administering the SERPINA3 therapeutic agent pointed to interesting effects on inhibiting neuronal death after cerebral ischemia.65 Serine protease inhibitors were significantly upregulated in our study. Here, SERPINA3 is linked to brain ischemia.