Even though dyslipidemia and inflammation are independent risk factors for cardiovascular disorders, we are assessing the interaction between serum lipids and highly sensitive C reactive protein levels among dyspeptic patients to predict potential cardiovascular disorders.<h4>Objectives</h4>To assess serum high sensitive C reactive protein levels and its correlation with lipid profile among dyspeptic patients.<h4>Methods</h4>A hospital-based comparative cross-sectional study was conducted from May 2022 to March 2023 in East Gojjam, Ethiopia. This evidence concerns the gene CRP and cardiovascular disorder.