GCG and type 1 diabetes mellitus: Adjunctive medications such as glucagon-like peptide 1 (GLP-1) receptor agonists and sodium glucose transporter 2 (SGLT-2) inhibitors administered alongside CLS to target post-prandial glucose control and potentially allow a fully closed-loop approach show feasibility although there are concerns around an increased risk of DKA in adults with T1D [72,81,82].