TLR4 and hereditary clear cell renal cell carcinoma: TLR4 is also targeted by tumor suppressor miRNAs like miR-216a in renal cell carcinoma [41], miR-145-5p in melanoma [42] and miR-122 in hepatocellular carcinoma [43], paralleling the miR-5195-3p/TLR4 axis in CRC.