The authors demonstrated that adenoviral-mediated neuronal PGRN expression leads to a reduction in neuropathological lipofuscinosis and microgliosis [23], and depletion of microglial PGRN did not aggravate the FTD/NCL-like phenotypes of mice deficient in neuronal PGRN [56]. This evidence concerns the gene GRN and neuronal ceroid lipofuscinosis.