MUTYH and neoplasm: It functions as a tumor suppressor and operates recessively, requiring biallelic or homozygous mutations to disable its function [130] Autosomal recessive familial adenomatous polyposis 2 (FAP2) is a condition, an individual inherits two different versions of the MUTYH gene, which is responsible for the base excision repair (BER) process [131].Two primary genetic alterations, p.Tyr179Cys (p.Y179C) and p.Gly396Asp (p.G396D), were identified in the Non-Hispanic white population [132].Another genetic mutation, namely c.1187G > A, was discovered an Egyptian [133].