ATM genes are linked to two- to four-fold a higher lifetime risk of breast cancer [89, 90].Moslemi et al. discovered that ATM missense mutations increase BC risk by a factor of 2.8 to 3.04 [91], with the c.7271T > G (rs28904921) missense mutation demonstrating the strongest association with BC [92, 93]. The gene discussed is ATM; the disease is breast carcinoma.