CALCA and Photophobia: Expanding on established light aversion models induced by chemicals, such as nitroglycerin or CGRP injections, which typically require 5–11 days for induction [18, 30]; we have developed a novel photophobia model induced by i.n. administration of UMB (150 μg/kg), under bright light in C57BL/6J mice (Fig. 1).