Notably, Scn8a that encodes a sodium voltage-gated channel, was also downregulated by photophobia with the highest fold change; Conversely, gene expression of Zmynd8, a risk locus in migraineurs [31], was markedly upregulated by photophobia, both of Scn8a and Zmynd8 DEGs were restored by the SFKs inhibitor (Fig. 6C and F). Here, SCN8A is linked to Photophobia.