Notably, Zmynd8, encoding the receptor of protein kinase C [44], is a risk locus in migraineurs [31]; However, knowledge on Zmynd8 linking with SFKs in migraine is sparse, albeit previous findings have shown that Src phosphorylation is critical for protein kinase C-mediated sensitization of transient receptor potential vanilloid-1 in vitro [48] and reciprocal interaction between protein kinase C and SFKs can upregulate the action potential firing activity in hypothalamic arcuate nucleus neurons [49]. The gene discussed is ZMYND8; the disease is migraine disorder.