For example, SIX1 is overexpressed in various human cancers, where it can transcriptionally regulate the expression and function of glycolysis-related genes, increasing the activity of key glycolytic enzymes like glucose transporter 1 (GLUT1) and hexokinase 2 (HK2), thereby promoting glycolysis and tumor growth(Li et al. 2018). The gene discussed is HK2; the disease is neoplasm.