Secondly, there is growing evidence to suggest that epigenetic marks can be inherited across generations, potentially influencing the susceptibility to obesity, i.e., Maternal obesity enhanced Zfp423 expression and adipogenic differentiation during fetal development, at least partially through reducing DNA methylation in the Zfp423 promoter, which is expected to durably elevate adipogenic differentiation of progenitor cells in adult tissue, programming adiposity and metabolic dysfunction later in life (Yang et al. 2013). Here, ZNF423 is linked to obesity due to melanocortin 4 receptor deficiency.