CDC25A and pancreatic ductal adenocarcinoma: In addition, Circulating Tumor Cells (CTCs) isolated from metastatic pancreatic ductal adenocarcinoma (PDAC) patients showed significantly increased CDC25A expression compared to untreated localized PDAC patients (n = 17) (Fig. 3f), suggesting that upregulated CDC25A in CTCs may promote tumor metastasis in vivo.